Welcome to A4liveCell Blog #6! SPAchip® as an image-based real-time readout of metabolic activity in genetic screening Understanding how the genetic information give rise to the phenotype, and how genomic perturbation affects a given phenotype are some of the main objectives of genetic screening. Recently, microscopy or FACS-based screening have emerged as new option to […]
Welcome to A4liveCell Blog #5! 3D Cell Culture Tips & Tricks: Zonal analysis of spheroid physiology with SPAchip® in real-time In drug discovery, 3D cellular spheroids have become a powerful model for high-content screening (HCS). Unlike traditional 2D cultures, spheroids more accurately mimic the in vivo environment, providing more reliable and physiologically relevant data. This […]
Welcome to A4liveCell Blog #4! Unlocking the Secrets of Ageing with SPAchip® technology As scientists delve deeper into the intricacies of ageing, they are uncovering a range of molecular hallmarks that hold the key to understanding this complex process. From telomere shortening to mitochondrial dysfunction, these mechanisms shape our journey through life, influencing our health […]
Welcome to A4liveCell Blog #3! SPAchip® technology enables the study of calcium signaling in receptor pharmacology. Calcium ions (Ca2+) are one of the most important signal transducers in cells, hence intracellular levels must be tightly regulated since prolonged high levels can lead to cell death. Since extracellular calcium concentration is usually 20,000-fold higher than intracellular […]
Work Site: Pozuelo de Alarcon. Madrid (SPA) About the Role: We are seeking a Data Image Analyst with expertise in High Content Screening (HCS) Techniques and Live Cell Imaging Software. This is an exceptional opportunity for a skilled professional to join our dynamic team and play a crucial role in advancing our innovative projects. Key […]
In the dynamic landscape of drug discovery, precision is paramount. High content screening (HCS) assays serve as indispensable tools, providing invaluable insights into cellular responses to various compounds. Yet, amidst the complexity of experimental design, two crucial factors often overshadowed are drug redosing and confluence levels, both wielding significant influence over assay outcomes. Drug Redosing: […]
Welcome to A4liveCell Blog #2! Unlocking Cellular Secrets with CytoCHECK SPAchip® In this edition of our blog, we’re excited to spotlight the transformative CytoCHECK SPAchip® technology, particularly focusing on our cutting-edge pH and Calcium multi-detection kits. These tools are not merely additions to the cell researcher’s toolkit; they represent a paradigm shift in how we […]
Welcome to the first A4 liveCell Blog! In this edition, we delve into the crucial aspects of cell studies Our focus today is on the innovative CytoCHECK SPAchip® pH detection kits, a game-changer in the field of cell research.In cell studies, maintaining optimal pH levels is not just important; it’s a necessity. Why, you ask? […]
The power of multiplexed live analytics in cell biology Cells are continuously challenged by insults and stimuli, including drugs and xenobiotics, from the extracellular environment. In response to these challenges, a series of intracellular molecules and ions act as signalling mediators, effectors or transducers which will ultimately result into physiological changes. In this context, noteworthy […]
A4cell is thrilled to mark the culmination of an exhilarating year with a significant milestone – the acquisition of a substantial €3 million investment. This momentous investment will serve as the catalyst for revolutionizing the landscape of living single cell analysis. The investment will primarily be channeled towards intensifying research and development efforts, expanding our […]
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