Welcome to A4liveCell Blog #4!
Unlocking the Secrets of Ageing with SPAchip® technology
As scientists delve deeper into the intricacies of ageing, they are uncovering a range of molecular hallmarks that hold the key to understanding this complex process. From telomere shortening to mitochondrial dysfunction, these mechanisms shape our journey through life, influencing our health and vitality. In this blog, we’ll explore these molecular hallmarks and
introduce SPAchip® technology—a groundbreaking tool for advancing ageing research and developing novel therapies.
Exploring Molecular Hallmarks of Ageing
Ageing is not merely a chronological process; it’s a culmination
of molecular changes within our cells. These changes manifest
in various ways:
- Genomic Instability: DNA damage accumulates with age due to environmental factors and cellular processes, leading to mutations and age-related diseases.
- Telomere Shortening: Telomeres shorten with each cell division, eventually causing cells to enter senescence or die, contributing to ageing.
- Epigenetic Alterations: Changes in DNA and histone modifications affect gene expression, leading to age-related cellular function changes.
- Loss of Proteostasis: The efficiency of protein folding and degradation declines with age, resulting in the accumulation of damaged proteins.
- Mitochondrial Dysfunction: Mitochondria produce energy less efficiently with age, contributing to cellular decline and disease.
- Cellular Senescence: Senescent cells accumulate with age and secrete inflammatory factors that can harm neighboring cells
By integrating SPAchip® technology into ageing research, scientists can dissect the molecular pathways driving age-related changes, such as monitoring oxidative stress, tracking metabolic fluctuations, and observing protein folding and degradation in real-time.
This deeper understanding facilitates the development of targeted interventions to mitigate age-related decline, enhance healthy ageing, and rejuvenate ageing cells. SPAchip® technology paves the way for novel therapies, from small molecule drugs to gene therapies, by precisely targeting the molecular hallmarks of ageing. These advancements promise a future where age is not a barrier to living fully, offering cost-effective, timely, high-quality, and versatile solutions.
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