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Mitochondrial health and pH changes as crucial drug discovery targets

Several mitochondrial dysfunctions have been linked with multiple human diseases, making mitochondria a crucial pharmacological target for the treatment of a broad range of diseases.

With its ability to specifically target mitochondria, researchers can gain valuable insights into the health and functionality of these vital cellular powerhouses. Mitochondrial stainings localize mitochondria of live cells and allows analyses of cell structure, tracing, tracking, cellular imaging, immunofluorescence staining & detection, mitochondria function, mitochondrial structure, and organelle tracing.

CytoCHECK SPAchip® pH Single-Detection Kit allows measurement of intracellular pH levels by changes in fluorescence intensity, which facilitates a more comprehensive study of the living single-cell physiology and maximizes the performance of most of imaging analyzers. In addition, mitochondrial health can be assessed by using mitochondrial staining. Incubating with both our SPAchip® technology and another commercial dye. Mitochondrial green staining intensity decreases in cells incubated with commercial dye at 24 and 48 hours after treatment, whereas cells incubated with SPAchip® displayed a fluorescence intensity similar to control, indicating fully functional mitochondrial structures.

Using mitochondrial staining together with our SPAchip® technology open the door for further research of mitochondrial status, function and activity in a diverse set of cellular assays (e.g. measure of mitochondrial membrane potential, oxigen consumption rate (OCR) and reactive oxygen species (ROS) production). By combining these two cutting-edge tools, researchers can accurately assess mitochondrial health and gain a deeper understanding of the impact of several treatments on these crucial cellular components.

The ability to visualize and track mitochondria using both technologies together opens up new avenues for studying mitochondrial dysfunction and developing targeted therapies for associated diseases. In conclusion, the combination of these powerful tools is a game-changer in the field of mitochondrial research.

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