SPAchip® Technology Concept
Today, we face a technological challenge: understanding metabolism's critical role in disease . Multiple biomolecule interactions can be analyzed in real time and cell processes can be tracked over time.
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Imagine a lab inside a living single cell capable of performing any analysis instantly and over time. SPAchip® technology makes this possible.
A4cell has seamlessly integrated microelectronic and cell biology expertise to develop a comprehensive solution for metabolic cell studies. Our cutting-edge technology enables researchers to effectively monitor and analyze cell behavior during disease progression. With our scientific approach, we strive to empower researchers with the insights they need to make significant strides in the field of cellular biology.
SPAchip® is the perfect tool for cell sensing
by dynamic film about cell feeling
State of the art
Advanced technology in living single cell
A4cell provides cutting-edge tools and technologies to enhance researchers' capabilities. Staying current is essential for a trusted scientist. We provide them with the latest tools and resources to support their work, encourage innovation, and advance the life sciences industry. Let's push science forward.
Introducing SPAchip® technology - a revolutionary solution for monitoring cellular pathways in real-time! Our intracellular silicon microchips are designed to be easily internalized in living cells without inducing physiological changes or affecting cell viability.
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Thanks to a cutting-edge miniaturization process, the SPAchips offer a highly precise and accurate way to analyse intracellular processes with multiple fluorescent probes. By simply changing the SPAchip® fluorescence, you can gain valuable insights into cellular activity. With the SPAchip® kit, you can save time and costs by using it with High Content Screening platforms and imaging analysers. It offers a user-friendly, yet powerful solution for monitoring cellular pathways that will help you take your research to the next level.
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So why wait? Try SPAchip® technology today and see the difference it can make for your research!
Real-time monitoring of cellular processes
In the study of diseases such as cancer, it's important to improve metabolic cell studies to answer the big questions. Live cell imaging techniques such as SPAchip® are fundamental to enhancing metabolic cell based assays.
First device in the market
for multiplexed living single cell analysis
A4cell is going to optimize its SPAchip© technology to offer high
added value to HCA l HCS and cell imaging platforms
The SPAchip® is the first intracellular device that can be multiplexed with probes emitting in the same wavelength. Surface functionalization techniques enable SPAchip® to be printed with nucleic acids, proteins, carbohydrates, lipids, or synthetic chemicals for tracking cell metabolism.
Print Procedure
In response to market demand and emerging trends in pharmaceutical and biotechnology research, A4Cell develops a wide range of kits
Thanks to a miniaturization process, A4Cell has obtained a device that can be
easily internalized in living cells without affecting the cell viability
or inducing physiological changes
Real images from image analyzer.
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A4cell develop specific kits depending on market demand and new trends in pharmaceutical and biotechnological research
SPAchip® offers the possibility to perform living single cell assays as:
• More sensitive by locally concentrating the fluorescent probe on the chip surface rather than in solution.
• Less toxic by reducing the total cytoplasmic concentration of fluorescent probes.
• Longer duration by fixing the probes on the chip and protecting them from dilution, excretion, or degradation.
• Highly discriminant of cytoplasmic readouts vs signals from other cell compartments.
• More informative by combining various probes on one chip simultaneously.
• More efficient by discriminating signals based on their relative position on the chip rather than their wavelength.
A4cell is delighted to present you a disruptive technology able to
analyze living single cells for extended periods offering innovative
assays with huge advantages:
VERSATILITY
LACK OF TOXICITY
TRACKING ABILITIES
MULTIPLE ANALYSIS POSSIBILITIES
ONE WAVELENGHT FITS ALL!
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Joining SPAchip®
on development applications
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SPAchip® technology does not expect to compete with other existing technologies. It opens the door to establish a new and more complete study of the living cell physiopathology with potential applications in academic research but also in drug discovery fields for Pharma and Biotech industry.
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Successfully tested, CytoCHECK SPAchip® Detection Kit can be used in combination with:
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High-content screening (HCS) Platforms
Are systems uses living cells as tools in biological research to elucidate the workings of normal and
diseased cells. These systems are a combination of modern cell biology, with all their molecular tools, with
automated high-resolution microscopy and robotic handling
Confocal Microscope
In this category the most frequent are confocal laser scanning (LCSM).
This is an optical imaging technique
for increasing optical resolution and contrast of a micrograph.
Cell Imaging Readers
Combines automated digital microscopy and conventional microplate detection in a configurable,
upgradable platform. The microscopy module offers up to 60x magnification in fluorescence, brightfield,
high contrast brightfield, color brightfield and phase contrast for maximum applications reach.
Live Cell Metabolic Assay Platforms
The Platform analyzes and measures metabolic functions of live cells with
same-day results. From routine analysis to cutting-edge research
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Flow Cytometry Systems
A technique used to detect and measure physical and
chemical characteristics of a population of cells or particles.
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Among others...
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What would you use SPAchip® technology for?
Tell us and help understanding and developing our product, contact us!