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Highlights

• Intracellular measurements of reactive oxygen species (ROS) levels (specifically hydroxyl radicals) by changes in fluorescence intensity.
• Designed to be active only when in contact with intracellular esterases.
• This product is pH-insensitive.
• Non-invasive for live cells allowing long-term monitoring of intracellular ROS changes.
• Composed of fluorescently labeled silicon microparticles that can be internalized in the cytosol
  of cultured cells.
• Ready-to-use workflow that provides an extensive study of cell physiology and metabolism.

Key features

• CytoCHECK SPAchip® kits are novel cell-based assays for living cells that bring together the fields of nanotechnology and cell biology.
• CytoCHECK SPAchip® detection kits are composed of fluorescently labeled silicon microparticles -SPAchips®- that can be internalized in cultured cells to monitor changes in specific intracellular analyte concentrations for long periods of time.
• This product enables a more comprehensive study of cell survival, proliferation, differentiation, cell death, apoptosis, and ferroptosis.
• CytoCHECK SPAchip® OHrad ROS Single-Detection Kit enables continuous, and accurate monitoring of intracellular ROS levels in living cells, by the specific detection of hydroxyl radicals (•OH).
• CytoCHECK SPAchip® OHrad ROS Single-Detection Kit is pH-insensitive: experimental readouts obtained from this product are not affected by pH changes of the media, avoiding measurement artifacts due to pH variations.
• CytoCHECK SPAchip® OHrad ROS Kit is only active when in contact with intracellular esterases, obtaining a fluorescent signal with internalized SPAchips.